The role of the urothelium in sensory signalling from the bladder

Abstract

The overall aim of this thesis is ‘to investigate the role of the urothelium in mediating sensory signalling from the bladder’ and provide direct evidence to support the hypothesis that the urothelium and afferent nerve fibres are capable of communicating with each other and via modulation of urothelial mediator release the activity of afferent nerve fibres can be altered .

Understanding the influence of the urothelium on afferent nerve sensitivity both during and between distensions of the bladder could reveal future targets for therapeutic intervention for treatment of lower urinary tract disorders, but equally importantly, contribute to our understanding of normal bladder function and the importance of a functioning urothelium in mediating afferent sensitivity.

Experiments in this thesis have explored the effect of urothelial signalling on afferent nerve sensitivity by several methods:-

1. Inhibition of urothelial mediator release – see chapter 4
2. Stimulation of urothelial mediator release – see chapter 5
3. Damage to the urothelium and the effect of K+ stimulation – see chapter 5
4. Pharmacological attenuation of urothelial signalling pathways – see chapter 6

Metadata

Supervisors:	Grundy, David
Awarding institution:	University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Science (Sheffield) > Biomedical Science (Sheffield)
Identification Number/EthosID:	uk.bl.ethos.581658
Depositing User:	Miss Laura Joy Gooch
Date Deposited:	05 Nov 2013 15:19
Last Modified:	03 Oct 2016 10:46
Open Archives Initiative ID (OAI ID):	oai:etheses.whiterose.ac.uk:4474

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