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Tissue manipulation using nano-particles ferrofluids for minimal access surgical applications

Lin, Yu-Sheng (2014) Tissue manipulation using nano-particles ferrofluids for minimal access surgical applications. PhD thesis, University of Leeds.

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Abstract

Nano-scale Iron-Oxide ferrofluids exhibit a special property, ‘superparamagnetism’, that induces an attractive force toward an external magnetic field. The aim of this project is to investigate the use of ferrofluids for tissue retraction during Minimally Access Surgery (MAS). In the in-vivo porcine experiments, 0.3 ml of ferrofluid (200 mg/ml concentration) containing 10 nm particles is injected subserosally into the small bowel, respectively. A 0.6 T magnetic field is created using a combination of 10 mm and 20 mm diameter Neodymium Iron Boron magnets. The vertical retraction distance is measured up to 80 mm and video-recorded. The results demonstrate the capacity of ferrofluid to facilitate the tissue manipulation and analysis of the migration of the particles within the tissue using micro computed tomography (CT). A theoretical model developed to validate the experimental results is also beneficial for predicting retraction force. In conclusion, this feasibility study provides a protocol for systematically using small volumes of ferrofluid, without the need to mechanically grasp the tissue.

Item Type: Thesis (PhD)
Keywords: Tissue manipulation, Ferrofluid, Magnetic retraction and adhesion, Minimal Access Surgery
Academic Units: The University of Leeds > Faculty of Engineering (Leeds)
The University of Leeds > Faculty of Engineering (Leeds) > School of Mechanical Engineering (Leeds)
The University of Leeds > Faculty of Engineering (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Thermofluids, Surfaces & Interfaces (iETSI) (Leeds)
Identification Number/EthosID: uk.bl.ethos.644771
Depositing User: MR. YU-SHENG LIN
Date Deposited: 21 Apr 2015 12:15
Last Modified: 25 Nov 2015 13:48
URI: http://etheses.whiterose.ac.uk/id/eprint/8569

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