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On the folding mechanism of the bacterial outer membrane protein PagP

Huysmans, G.H.M (2008) On the folding mechanism of the bacterial outer membrane protein PagP. PhD thesis, University of Leeds.

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Abstract

Membrane proteins represent an important class of macromolecules that play critical roles in many biological processes. The energetic principles underlying their stability, however, are not well understood. To address this deficiency, the kinetics and thermodynamics of the folding of the Escherichia coli outer membrane protein PagP were investigated by exploiting the ability of this polypeptide to refold into detergent micelles and into artificial lipid membranes. Investigations using the latter enabled the contributions to the folding process of both the protein sequence and of the bilayer lipid oomposition to be discerned.

Item Type: Thesis (PhD)
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > Institute of Membrane and Systems Biology (Leeds)
Identification Number/EthosID: uk.bl.ethos.493545
Depositing User: Ethos Import
Date Deposited: 22 Sep 2015 11:41
Last Modified: 22 Sep 2015 11:41
URI: http://etheses.whiterose.ac.uk/id/eprint/6752

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