White Rose University Consortium logo
University of Leeds logo University of Sheffield logo York University logo

Mechanistic Studies into the Catalytic Activity of Half-Sandwich Ruthenium Complexes

Mistry, Neetisha Shantilal (2013) Mechanistic Studies into the Catalytic Activity of Half-Sandwich Ruthenium Complexes. PhD thesis, University of York.

Text (PDF file )
Final Thesis Neetisha Mistry.pdf
Available under License Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 UK: England & Wales.

Download (10Mb) | Preview


A mechanistic investigation into the catalytic activity of half-sandwich ruthenium complexes, [Ru(η5-C5H5)(L)3]+ (where L = phosphorus- or nitrogen- donating ligands ) for the alkenylation of pyridine is reported. Mechanistic studies have demonstrated that [Ru(η5-C5H5)(PPh3)(NC5H5)2][PF6] is an important intermediate in the formation of E-2-styrylpyridine derivatives. Collaboration between the reported experimental and additional theoretical studies (conducted by David Johnson) has allowed for a catalytic cycle for the alkenylation of pyridine to be proposed, highlighting the role of vinylidene and pyridylidene ligands. A general synthetic procedure for a range of [Ru(η5-C5H5)(PR3)(L)2][PF6] complexes from [Ru(η5-C5H5)(NCMe)3][PF6] was performed, where R = Ph, Me, iPr, OPh; and L = pyridine, 3-methylpyridine, 4-methylpyridine, 4-dimethylaminopyridine, 1-methylimidazole, t-butylimidazole. The properties of these complexes have been investigated. The reactivity of [Ru(η5-C5H5)(PPh3)(NC5H5)2][PF6] with terminal alkynes was investigated in two different reaction media (dichloromethane and pyridine). The stoichiometric reaction of [Ru(η5-C5H5)(PPh3)(NC5H5)2][PF6] with phenylacetylene in a dichloromethane solution generated a vinylidene-containing intermediate [Ru(η5-C5H5) (PPh3)(NC5H5)(=C=CHPh)][PF6]. This reacts further to produce a pyridylidene-containing complex [Ru(η5-C5H5)(PPh3)(κ3-C3-C5H4NCH=CHPh)][PF6]. Upon the addition of excess pyridine a 1-ruthanaindolizine species is generated. Similar observations have been made with alkynes HC≡CR (where R = 4-F-C6H4, 4-CF3-C6H4) and [Ru(η5-C5H5)(PPh3)(L)2][PF6] (where L = 3-methylpyridine, 4-methylpyridine, 4-dimethylaminopyridine) and the substituent effects and properties of the pyridylidene-containing complexes are compared to the literature. The addition of phenylacetylene or 4-ethynyl-α,α,α-trifluorotoluene to [Ru(η5-C5H5) (PPh3)(NC5H5)2][PF6] in a pyridine solution at 50 °C produces 2-substituted E-styrylpyridine derivatives in a 100 % atom efficient manner. The formation of the 1-ruthanaindolizine complex results in catalyst deactivation. A range of reaction conditions have been investigated to identify the optimum catalyst performance.

Item Type: Thesis (PhD)
Keywords: ruthenium, half-sandwich, vinylidene, pyridylidene, pyridine, C-H functionalisation, catalysis, mechanistic studies.
Academic Units: The University of York > Chemistry (York)
Identification Number/EthosID: uk.bl.ethos.595140
Depositing User: Miss Neetisha Shantilal Mistry
Date Deposited: 07 Mar 2014 16:06
Last Modified: 08 Sep 2016 13:30
URI: http://etheses.whiterose.ac.uk/id/eprint/5282

You do not need to contact us to get a copy of this thesis. Please use the 'Download' link(s) above to get a copy.
You can contact us about this thesis. If you need to make a general enquiry, please see the Contact us page.

Actions (repository staff only: login required)