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The role of concomitant drugs in the aetiology of fatal heroin- and methadone- related overdose

Oliver, Phillip (2008) The role of concomitant drugs in the aetiology of fatal heroin- and methadone- related overdose. PhD thesis, University of Sheffield.

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Heroin and methadone poisoning are significant causes of death of young people in the United Kingdom. In a high proportion of these fatalities concomitant substances are also detected. This thesis is concerned with the significance of this observation and the hypothesis that these substances are risk factors for fatal heroin- and methadone-related overdose. A referential database was developed incorporating post-mortem toxicology data from 1,222 heroin and methadone overdose fatalities from around England and Wales. The most commonly detected concomitant drugs were ethanol, diazepam, temazepam, an additional opioid and cocaine. In the first of two studies, statistical models were derived, using multiple linear regression, to assess the potential effect of these concomitant substances on the lethality of heroin and methadone. Log-log and semi-log models were considered and regression coefficients were estimated by ordinary least squares. Ethanol blood concentrations were associated with significantly reduced blood levels of total morphine and methadone, consistent with a causal role for this substance. There was an absence of evidence of a similar effect for other commonly detected concomitants.

Item Type: Thesis (PhD)
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield)
Other academic unit: Academic Unit of Primary Medical Care
Identification Number/EthosID: uk.bl.ethos.489057
Depositing User: EThOS Import Sheffield
Date Deposited: 22 Jul 2013 15:26
Last Modified: 08 Aug 2013 08:52
URI: http://etheses.whiterose.ac.uk/id/eprint/3639

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