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Studies on the prebiotic origin of 2-deoxy-D-ribose

Steer, Andrew Mark (2017) Studies on the prebiotic origin of 2-deoxy-D-ribose. PhD thesis, University of York.

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This research attempts to provide a possible explanation to the chemical origin of 2-deoxy-D-ribose via an aldol reaction of acetaldehyde and D-glyceraldehyde. The sugar mixture is trapped with N,N-diphenylhydrazine for ease of purification and characterisation. The reaction is promoted by amino acids, amino esters and amino nitriles consistently giving selectivities in favour of 2-deoxy-D-ribose. This is the first example of an amino nitrile-promoted reaction. The research is developed further by exploring the formation of 2-deoxy-D-ribose in a "protocell" environment - a primitive cell. Here we suggest that primitive cells may have been simple hydrogel systems. A discussion of the characterisation and catalytic ability of small peptide-based structures is included.

Item Type: Thesis (PhD)
Related URLs:
Academic Units: The University of York > Chemistry (York)
Identification Number/EthosID: uk.bl.ethos.731584
Depositing User: Mr Andrew Mark Steer
Date Deposited: 26 Jan 2018 16:17
Last Modified: 24 Jul 2018 15:24
URI: http://etheses.whiterose.ac.uk/id/eprint/19070

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