Tahir, Naveed (2024) Histidine modifications in peptides: Impact on anticancer activities. MPhil thesis, University of Sheffield.
Abstract
Peptide-based therapeutics have emerged as a promising avenue in the development of novel anticancer strategies, offering potential for high specificity and reduced toxicity compared to conventional treatments. This study explored the anticancer potential of a set of rationally designed peptides, focusing on the impact of specific amino acid modifications. Human cancer and non-cancer cell lines were used to assess biological activity through a range of biochemical and imaging-based techniques. Preliminary findings suggest that certain modifications may influence cellular uptake and selective cytotoxicity. These results lay the groundwork for further investigations into peptide-mediated drug delivery systems and their potential application in cancer therapy.
Certain details have been redacted to protect intellectual property and future publication opportunities.
Metadata
Supervisors: | Brown, Stephen and Rainero, Elena |
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Keywords: | anticancer peptides; histidine modification; peptide-based therapeutics; siRNA delivery; microscale thermophoresis; high-content microscopy; colorectal cancer; HCT116; Caco-2; HFF-1; cellular uptake; cytotoxicity; peptide–nucleic acid interaction |
Awarding institution: | University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) |
Date Deposited: | 06 Oct 2025 10:47 |
Last Modified: | 06 Oct 2025 10:47 |
Open Archives Initiative ID (OAI ID): | oai:etheses.whiterose.ac.uk:37160 |
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