New Routes to α-Arylated N-Boc Heterocycles

In this thesis methods for the α-arylation of nitrogen heterocycles via palladium-catalysed cross-coupling were investigated. The focus of this thesis was to establish methodology that would be particularly useful for medicinal chemists, methodology that would be: synthetically straightforward, easy to carry out and tolerable of the cross-coupling of nitrogen-containing heteroaryl halides, which are prevalent in biologically active molecules. The secondary aim was to develop methodology that would be amenable to rapid screening for the use in structure activity relationship programmes.