An investigation into pyocyanin-triggered carbon monoxide-releasing molecules

Pseudomonas aeruginosa (P. aeruginosa) infection is the most common cause of death amongst Cystic Fibrosis patients. Its virulence factor pyocyanin is of interest as a redox-active compound and has been investigated herein.

Carbon-monoxide-releasing molecules have been developed in recent years to deliver carbon monoxide (CO), a known antimicrobial, safely and specifically to where it is required. Pyocyanin has been identified as a potential target to trigger CO-release as it is produced almost exclusively by P. aeruginosa.