Histidine modifications in peptides: Impact on anticancer activities

Peptide-based therapeutics have emerged as a promising avenue in the development of novel anticancer strategies, offering potential for high specificity and reduced toxicity compared to conventional treatments. This study explored the anticancer potential of a set of rationally designed peptides, focusing on the impact of specific amino acid modifications. Human cancer and non-cancer cell lines were used to assess biological activity through a range of biochemical and imaging-based techniques. Preliminary findings suggest that certain modifications may influence cellular uptake and selective cytotoxicity. These results lay the groundwork for further investigations into peptide-mediated drug delivery systems and their potential application in cancer therapy.

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