Electrophilic functionalisation of indoles

This Thesis describes efforts to develop improved methods to synthesise spirocyclic scaffolds based on indole through the development of a novel library of bis-electrophilic reagents. These spiroannulation reagents (SARs) are designed to undergo a two-bond forming spiroannulation reaction with heteroaromatic cores in a one-pot process, rapidly accessing the corresponding spirocycle. Indole is the chosen heteroatomic core throughout this Thesis due to its favourable reactivity and prevalence in biologically active molecules.