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Differentiation of human embryonic stem cells to the pancreatic lineage

Murad, Nadia Yousif (2008) Differentiation of human embryonic stem cells to the pancreatic lineage. PhD thesis, University of Sheffield.

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Abstract

Human embryonic stem (hES) cells have great therapeutic potential for the treatment of degenerative conditions such as Parkinson's disease, cardiac failure and type I diabetes. This potential is based on the ability of hES cells in vitro to self-renew and also differentiate to cells of all three germ layers; ectoderm, mesoderm and endoderm. Type I diabetes is due to an autoimmune disease destroying the insulin-secreting cells of the pancreas (β-cells) that regulate plasma glucose concentration. The pancreas develops from the endoderm lineage. 2. To find a cure for type I diabetes based on the use of hES, it is essential to understand the differentiation process of ES cells into the endodermal, β-cell lineage. The aim of this study was to investigate the generation of insulin-secreting cells using hES cells in vitro and to compare sue with those in the developing pancreas of the foetus.

Item Type: Thesis (PhD)
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield)
Other academic unit: Centre for Stem Cell Biology
Identification Number/EthosID: uk.bl.ethos.489056
Depositing User: EThOS Import Sheffield
Date Deposited: 20 May 2014 15:17
Last Modified: 20 May 2014 15:17
URI: http://etheses.whiterose.ac.uk/id/eprint/6102

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