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Neutral dendrimer approach towards protein binding

Althobaiti, Ibrahim (2020) Neutral dendrimer approach towards protein binding. PhD thesis, University of Sheffield.

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Abstract

This study explored the factors that would maximally facilitate the binding of encapsulated neutral dendrimers to protein. The study had two aims. Firstly, to identify the factors that would achieve best encapsulation of the linear chain; factors included hydrophobicity and varying the length number of hydrogen bonds in the linear chain e.g. one H-bond (1HB-LC), two H-bonds (2HB-LC) and three H-bonds (3HB-LC). Secondly, the study aimed to establish how binding was moderated by functionalising the linear chains with various amino acids.

Item Type: Thesis (PhD)
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > Chemistry (Sheffield)
The University of Sheffield > Faculty of Science (Sheffield) > Molecular Biology and Biotechnology (Sheffield)
Depositing User: Mr Ibrahim Althobaiti
Date Deposited: 19 May 2020 15:40
Last Modified: 19 May 2020 15:40
URI: http://etheses.whiterose.ac.uk/id/eprint/26853

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