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Effect of Vitamin D and Whole Body Vibration on High Resolution peripheral Quantitative Computed Tomography (HR-pQCT) Parameters of the Distal Tibia

Alshamrani, Hassan A (2019) Effect of Vitamin D and Whole Body Vibration on High Resolution peripheral Quantitative Computed Tomography (HR-pQCT) Parameters of the Distal Tibia. PhD thesis, University of Sheffield.

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PhD Thesis - Hassan Alshamrani.pdf
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Vitamin D, calcium and physical activity are important factors for bone health. A cross sectional study was conducted in Chapter 2 to assess vitamin D intake, calcium intake and physical activity among children with wrist or ankle injuries and their association with fracture risk. The majority of children had low vitamin D and calcium intake. The logistic regression indicated that there was a small but significant relationship between calcium intake and fracture risk (OR per SD increase = 0.998; 95% CI, 0.997 – 0.999) but no significant relationship was found between vitamin D intake and fracture risk. In the following section (Chapters 3, 4, 5 and 6), a randomised controlled trial was conducted to determine the effect of whole body vibration and a large single dose of vitamin D (150,000 IU) on bone density of the distal tibia as measured by HRpQCT. The study consisted of four parallel groups of equal numbers (40 in total); WBV and placebo group, placebo group, vitamin D group and vitamin D+ WBV group. Measurements (HR-pQCT, serum 25 (OH)D, PTH, bone profile) were collected at baseline and after 12 weeks (during week 13). The median baseline serum 25(OH)D for all participants was 23 nmol/L. The high dose of vitamin D was well tolerated. There was a significant increase in serum 25 (OH)D in vitamin D and vitamin D+WBV groups relative to the placebo group (all p<0.01). There was a significant decrease in PTH in vitamin D group relative to the placebo group (p=0.013). After 12 weeks, vitamin D group showed the greatest increase in total bone density (increased by 2.7 mg/cm3 relative to the placebo group, p= 0.05). The main findings of this study indicated that the large single dose of vitamin D and 12 weeks of WBV did not improve bone density, bone microarchitecture or bone strength.

Item Type: Thesis (PhD)
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Medicine (Sheffield)
Depositing User: Hassan A Alshamrani
Date Deposited: 08 Apr 2019 08:07
Last Modified: 08 Apr 2019 08:07
URI: http://etheses.whiterose.ac.uk/id/eprint/23523

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