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Evaluation of CD8+ T-cell numbers and repertoires

Ferrarini, Marco (2018) Evaluation of CD8+ T-cell numbers and repertoires. PhD thesis, University of Leeds.

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Abstract

This thesis tackles the problem of T-cell receptor (TCR) diversity, from two different points of view. On one hand, the observed TCR diversity is studied from a mathematical perspective, concentrating on the probability of a sample to reproduce a certain percentage of the total TCR diversity. On the other hand, biological samples are considered, focusing on statistical analysis of the observed VDJ gene segments. To conclude, a stochastic model is developed to explore the population dynamics of a simulated TCR repertoire. Computer simulations complete this multidisciplinary approach, helping verifying the different mathematical theories behind the stochastic models.

Item Type: Thesis (PhD)
Keywords: Mathematics, Immunology, T-cell, CD8, modelling
Academic Units: The University of Leeds > Faculty of Maths and Physical Sciences (Leeds) > School of Mathematics (Leeds) > Applied Mathematics (Leeds)
Depositing User: Dr. Marco Ferrarini
Date Deposited: 04 Oct 2018 15:45
Last Modified: 04 Oct 2018 15:45
URI: http://etheses.whiterose.ac.uk/id/eprint/21520

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