White Rose University Consortium logo
University of Leeds logo University of Sheffield logo York University logo

New Ruthenium tach Complexes as Water-Soluble Chemotherapy Agents

arkawazi, Sham (2017) New Ruthenium tach Complexes as Water-Soluble Chemotherapy Agents. PhD thesis, University of York.

This is the latest version of this item.

SWQ thesis.pdf - Examined Thesis (PDF)
Available under License Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 UK: England & Wales.

Download (4Mb) | Preview


Ruthenium complexes are currently attracting much attention in the field of medicinal chemistry as they provide numerous properties which make them an appropriate candidate for drug design. Recently, a series of ruthenium tach complexes with extremely high in vitro activity and high solubility have been developed. Cis-1,3,5-triaminocyclohexane (tach) provides a hydrogen bond donor through amine groups, which aids both solubility and interaction with biomolecules. The chemistry of the ruthenium tach complexes was developed in order to understand their activity in a biological environment. The parent compound, tach [2] was modified by the incorporation of a new functional group (benzyl) into the coordination sphere of the ligand and synthesis a new tach analogue, tachmb [3]. The coordination chemistry of [3] was performed with a range of different ruthenium precursors to yield [Ru(tachmb)(DMSO)Cl2] [5], [Ru(tachmb)(PPh3)Cl2] [7], and [Ru(tachmb)(dppb)Cl]Cl [9]. The anti-proliferative activity of the modified tach [3] and the complexes were evaluated with in vitro tests against A549 (human lung cancer) and A2780 (human ovarian cancer) cell lines. The activity of [3] showed mild activity in comparison to the non-toxic tach, [2]. Both complexes [7] and [9] showed high activity; in particular, the activity of [9] was found to exceed that of cisplatin in both cell lines. Two new analogues of ruthenium tach complexes tagged with fluorescent ligands were synthesised and fully characterised, [Ru(tach)(FL-I)Cl]Cl [10] and [Ru(tach)(FL-II)Cl]Cl [13]. Two previously reported complexes were also prepared; one complex with high cytotoxic activity ([Ru(tach)(dppp)Cl]Cl, [11]) and one complex with light sensitive behaviour ([Ru(tach)(phen)(DMSO)], [12]). The interactions of these complexes with Calf Thymus DNA (CT-DNA) and bovine serum albumin (BSA) were examined spectrophotometrically. The results show intercalation behaviour of [10] and [12] towards DNA while complex [11] instead exhibits high binding affinity towards BSA. The cytotoxicity of the complexes indicates that proteins may be the potential biological targets of ruthenium tach anti-cancer drugs.

Item Type: Thesis (PhD)
Academic Units: The University of York > Chemistry (York)
Identification Number/EthosID: uk.bl.ethos.731573
Depositing User: Mrs Sham arkawazi
Date Deposited: 17 Jan 2018 16:08
Last Modified: 24 Jul 2018 15:23
URI: http://etheses.whiterose.ac.uk/id/eprint/18881

Available Versions of this Item

  • New Ruthenium tach Complexes as Water-Soluble Chemotherapy Agents. (deposited 17 Jan 2018 16:08) [Currently Displayed]

You do not need to contact us to get a copy of this thesis. Please use the 'Download' link(s) above to get a copy.
You can contact us about this thesis. If you need to make a general enquiry, please see the Contact us page.

Actions (repository staff only: login required)