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Analysing the Reactivity and Mechanisms of Artificial Substrates for Biological Catalysts

Al Hussain, Adel (2017) Analysing the Reactivity and Mechanisms of Artificial Substrates for Biological Catalysts. PhD thesis, University of Sheffield.

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Abstract

It has recently been noted that enzymes can be promiscuous in their activity, and catalyse the reactions of a range of functional groups, including those not found in natural systems. Defining the fundamental details of these reactions will assist in understanding the chemical basis for this observation. This thesis describes phosphoryl and sulfuryl transfer reactions, using Free Energy Relationship (FER) to investigate their transition states.

Item Type: Thesis (PhD)
Additional Information:
Keywords: LFER, hydrolysis, phosphoryl and sulfuryl transfer reactions.
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > Chemistry (Sheffield)
Depositing User: Mr Adel Alhussain
Date Deposited: 01 Sep 2017 10:31
Last Modified: 01 Sep 2017 10:31
URI: http://etheses.whiterose.ac.uk/id/eprint/17998

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