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Structure/function analysis of hRme-6, a rab5 GEF that integrates trafficking and signaling

Zhu, Zhou (2017) Structure/function analysis of hRme-6, a rab5 GEF that integrates trafficking and signaling. PhD thesis, University of Sheffield.

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Abstract

There is increasing understanding that endocytosis and signalling are linked to each other. Signalling receptors are particularly interesting as cargoes which are precisely regulated through the process of endocytosis. However it is still not clear that how the overlap between endocytosis and signalling occurs mechanistically. Rme-6, a Rab5 GEF, is a potential candidate that is involved in the endocytosis of transferrin and EGFR and also the signalling pathway of Ang1-Tie2. The objective of this thesis was to investigate the structure/function relationship of hRme-6 to understand how it integrates trafficking and signalling processes.

Item Type: Thesis (PhD)
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > Biomedical Science (Sheffield)
The University of Sheffield > Faculty of Science (Sheffield)
Depositing User: Miss Zhou Zhu
Date Deposited: 28 Jul 2017 14:03
Last Modified: 28 Jul 2017 14:03
URI: http://etheses.whiterose.ac.uk/id/eprint/17764

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