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Total Synthesis of the C-1 – C-19 Fragment of Phorboxazoles

Zhao, Yuxiong (2017) Total Synthesis of the C-1 – C-19 Fragment of Phorboxazoles. MSc by research thesis, University of York.

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Phorboxazoles have become interesting synthetic target, because of their challenging molecular structure and their potent anticancer, antifungal, and antibiotic activity. In this study, two different strategies are used to form two tetrahydropyran rings in the fragment of C-1 – C-19 of phorboxazoles. The first strategy was designed to use oxazole aldehyde as the starting material through Wittig reaction, whereas the second approach was assumed using oxazole methyl ketone by cross metathesis. The key reaction in both strategies will be the application of our developed stereodivergent oxy-Michael reaction methodology.

Item Type: Thesis (MSc by research)
Keywords: Phorboxazoles, aldol reaction, cross metathesis.
Academic Units: The University of York > Chemistry (York)
Depositing User: Mr Yuxiong Zhao
Date Deposited: 06 Jun 2017 10:47
Last Modified: 06 Jun 2017 10:47
URI: http://etheses.whiterose.ac.uk/id/eprint/17392

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