γ-cyclodextrin metal-organic frameworks for controlled release

This thesis explored the use of γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) as a controlled-release delivery method for curcumin, a bioactive compound with significant pharmacological properties but low bioavailability due to low solubility and rapid degradation. The research aims to enhance the solubility, stability, and bioaccessibility of curcumin by utilizing the unique structural functional features of γ-CD-MOFs, which combine the porous nature of metal-organic frameworks with the biocompatibility of cyclodextrins.
The synthesis of γ-CD-MOFs was investigated after a thorough review that highlighted its distinct structural characteristics, biocompatibility, and potential as delivery vehicles for bioactive compounds. This demonstrated that the choice of solvent had a major impact on crystal morphology and that the porosity was essential to the functional performance of γ-CD-MOFs. Further investigation of the interaction between curcumin and γ-CD-MOFs indicated that curcumin may be present on crystal surfaces or between γ-CD pairs, in addition to the hydrophobic cavities of γ-CD-MOFs, affecting its release profile. Investigations into the synergistic effects of γ-CD-MOFs with surfactant micelles revealed that curcumin’s apparent solubility and bioaccessibility were improved. However, when γ-CD-MOFs were incorporated into emulsion systems, it became clear that they were unstable in acidic gastric conditions. A promising delivery method for preventing γ-CD- MOFs from degrading was found to be capsule-based delivery, enabling prolonged release as well as enhanced intestinal bioaccessibility and absorption.
In summary, this thesis highlights the potential of γ-CD-MOFs as a versatile and effective delivery system for controlled release, offering a pathway to enhance the bioavailability of curcumin and potentially other poorly soluble bioactive compounds. These insights contributed to the growing body of knowledge on γ-CD-MOFs, paving the way for their application in pharmaceutical and functional food formulations.