Macromolecules for drug delivery

The optimization of drug delivery systems (DDSs) is essential for improving drug therapy
effectiveness and solving people's health problems. There has been a growing interest in
dendrimers in academia and industry in recent years. The most prominent feature of their
application is that they are capable of delivering hydrophobic, poorly soluble molecules to
specific sites. The internal space of dendrimers can be used to host small guest molecules, and
able to host small guest molecules through secondary interactions in cases of high generational
dendrimers. However, the high cost and time required to synthesize dendrimers limit their use.
A simple and cheaper solution may be available through the use of hyperbranched polymers
(HBP) if they can achieve the same results as dendrimers. In this research, we compare the
encapsulation ability of two different HBPs with dendrimers for applications in drug delivery