Mechanisms of endosomal permeability: A route to enhancing the cytosolic delivery of endocytosed therapeutics

One of the rate-limiting steps for the cytosolic delivery of endocytosed therapeutics is endosomal escape. An increase in endosomal release would increase the therapeutic output of current therapeutics, as well as allowing the use of novel therapeutics that currently cannot be successfully delivered to the correct cellular location. The cellular mechanisms involved in maintaining endosomal integrity and endosomal release are not fully understood and our work here aims to increase our understanding of endosomal release.