London - South East Research Ethics Committee
Equinox House
City Link
Nottingham
NG2 4LA

Tel: N/A
Fax: N/A

22 April 2022

Erica Wallis
Sheffield Teaching Hospitals NHS Foundation Trust
1st Floor, 11 Broomfield Road, 
Sheffield
S10 2SE

Dear Erica Wallis

Study title:	Bridging the Age Gap in Breast Cancer: Improving Outcomes for Older Women.	
REC reference:	12/LO/1808	
Protocol number:	DBH 0530/2013/NCT	
Amendment number:	1145/2022/NCTS	
Amendment date:	11 February 2022	
IRAS project ID:	115550	

Thank you for submitting the above amendment, which was received on 11 February 2022.  It is noted that this is a modification of an amendment previously rejected by the Committee (our letter of 14 March 2022 refers).

The modified amendment was reviewed on 1st April 2022 by the Sub-Committee in correspondence. A list of the members who took part in the review is attached. 

Ethical opinion

I am pleased to confirm that the Committee has given a favourable ethical opinion of the modified amendment on the basis described in the notice of amendment form and supporting documentation.

Approved documents

The documents reviewed and approved are:

Document  	Version  	Date  	 
Other [AMENDMENT TOOL - Modified] 	1.6 	11 February 2022 	 
Other [Cover Letter] 	n/a 	21 March 2022 	 
Research protocol or project proposal [Protocol Submitted with Original Amendment V1.1 22 Feb 2022] 	1.1 	22 February 2022 	 

R&D approval

All investigators and research collaborators in the NHS should notify the R&D office for the relevant NHS care organisation of this amendment and check whether it affects R&D approval of the research.

Statement of compliance

The Committee is constituted in accordance with the Governance Arrangements for Research Ethics Committees and complies fully with the Standard Operating Procedures for Research Ethics Committees in the UK.

HRA Learning

We are pleased to welcome researchers and research staff to our HRA Learning Events and online learning opportunities– see details at: https://www.hra.nhs.uk/planning-and-improving-research/learning/

IRAS Project ID - 115550: 				Please quote this number on all correspondence

Yours sincerely

pp. Owain Richardson

Dr Anthony Fox
Chair

E-mail: londonsoutheast.rec@hra.nhs.uk

Enclosures:	List of names and professions of members who took part in the review	

Copy to:	Ms Lynda Wyld, University of SheffieldConfidentiality Advise Team	

London - South East Research Ethics Committee

Attendance at Sub-Committee of the REC meeting on 01 April 2022

Committee Members: 

Name  	Profession  	Present  	 Notes  	 
Dr Anthony Fox  	Pharmaceutical Physician 	Yes 	  	 
Dr Karen  Ma 	Retired Consultant 	Yes 	  	 
 
Also in attendance: 

Name  	Position (or reason for attending)  	 
 Chane Roodt 	Approvals Administrator