Examination of Palladium Catalyst Structure in Regioselective Suzuki Miyaura Cross-Coupling Reactions

Catalysis plays a vital role in chemical synthesis, from organic catalysis to metal catalysis. Palladium is able to affect many catalytic organic transformations, e.g. cross-coupling reactions, which are of great value to the synthetic chemist. While many reactions are mediated by homogeneous Pd species, there is good experimental evidence supporting a role for higher order Pd species that can operate in a quasi-heterogeneous manner. Indeed, in some cases, stabilised Pd nanoparticles mediate heterogeneous cross-coupling reactions. Many researchers have reported use of Pd(PPh3)4 catalysts in cross-coupling chemistry. Until this study little has been reported on Pd catalyst screening against SMCCs, comparing homogeneous, heterogeneous and ‘quasi’ homo/heterogeneous Pd catalysts