White Rose University Consortium logo
University of Leeds logo University of Sheffield logo York University logo

Dissolution behaviours of structured particles

Li, Changdong (2014) Dissolution behaviours of structured particles. PhD thesis, University of Leeds.

CHANGDONG LI- PHD Final Thesis Hard Copy.pdf - Final eThesis - complete (pdf)
Available under License Creative Commons Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales.

Download (10Mb) | Preview


The work presented in this thesis aims at the fundamental understanding and investigation of dissolution behaviors of structured particles. This topic is relevant to numerous industrial applications including detergent, pharmaceutical, agrochemical and energy products. Both experimental works and theoretical analyses were carried out in this work. The particles of several different materials including sodium carbonate and polymers with specific characteristic and structure were used into the experimental works in this thesis. Polymers used in this thesis included carboxymethyl celluslose, croscarmellose sodium and crospovidone. The studies on characteristics of these particles included the determination of particle size, shape and structure with several measurement techniques. The dissolution process was measured with experimental methods under different solution conditions including temperature, stirring speed and pH. Based on these measured data, the dissolution kinetics such as dissolution rate constant were quantified with mathematical models and analyzed with theoretical studies. In this way, the dissolution behaviors of different structured particles could be finally identified and analyzed with the quantified data of dissolution process and dissolution kinetics. Additionally according to the quantification process, the effects of these solution conditions on dissolution kinetics could also be determined and identified that how these conditions impact dissolution kinetics. Main conclusions of my work on dissolution experiments in this thesis were simply summarized as the following that: • An increasing in the temperature and stirring speed leads to the increases of dissolution rate and dissolution rate constant of sodium carbonate particles in all cases. • The dissolution rate and the rate constant decreases with the increasing of pH value of solution. • Carboxymethyl cellulose and crospovidone show a clear effect to enhance the dissolution rate and the rate constant of sodium carbonate-polymer composite tablets. • Cropovidone also has a stronger effect to enhance the dissolution process and kinetics than carboxymethyl cellulose • Croscarmellose sodium shows a clear effect to weaken the dissolution rate and the rate constant of sodium carbonate-polymer composite tablet.

Item Type: Thesis (PhD)
Keywords: Sodium carbonate; Carboxymethyl cellulose; Croscarmellose sodium; Crospovidone; Tablet; Single particle; Dissolution; Dissolution kinetics; Conductivity; Image analysis
Academic Units: The University of Leeds > Faculty of Engineering (Leeds) > School of Chemical and Process Engineering (Leeds)
The University of Leeds > Faculty of Engineering (Leeds) > School of Chemical and Process Engineering (Leeds) > Institute of Particle Science and Engineering (Leeds)
Identification Number/EthosID: uk.bl.ethos.638910
Depositing User: CHANGDONG LI
Date Deposited: 04 Mar 2015 09:43
Last Modified: 25 Nov 2015 13:48
URI: http://etheses.whiterose.ac.uk/id/eprint/7954

You do not need to contact us to get a copy of this thesis. Please use the 'Download' link(s) above to get a copy.
You can contact us about this thesis. If you need to make a general enquiry, please see the Contact us page.

Actions (repository staff only: login required)