Cardiovascular Magnetic Resonance Imaging for the Investigation of Patients with Coronary Heart Disease

Objectives To evaluate the role of stress perfusion cardiovascular magnetic resonance (CMR) in the investigation of stable coronary artery disease (CAD). Background Coronary artery disease remains the biggest cause of morbidity and mortality. The multi-parametric CMR examination is established as an investigative strategy for the investigation of CAD. Methods Study 1 & 2: Patients with stable coronary artery disease underwent a multi-parametric CMR protocol assessing 4 components: i) left ventricular function; ii) myocardial perfusion; iii) viability (late gadolinium enhancement (LGE)) and iv) coronary magnetic resonance angiography (MRA). The diagnostic accuracy of the individual components were assessed. The ischaemic burden of stress CMR Vs. Single Photon Emission Computed Tomography (SPECT) was determined. Study 3: Volunteers and patients were scanned with perfusion sequence which adapts the spatial resolution to the available scanning time and field-of-view. Study 4: A multi-centre pragmatic randomised controlled trial of patients with stable angina comparing CMR guided-care Vs. SPECT guided-care Vs. National Institute of Health and Care Excellence guided-care. Results Study 1 demonstrated the stress perfusion component of the multi-parametric CMR exam was the single most important component for overall diagnostic accuracy. However, the full combined multi-parametric protocol was the optimal approach for disease rule-out, and the LGE component best for rule-in. Study 2 showed that there was reasonable agreement of the summed stress scores between CMR and SPECT (a well established investigation with significant amounts of prognostic data). In study 3, a perfusion pulse sequence which automatically adapts the acquisition sequence to the available scanning time results in spatial resolution improvement and reduction in dark rim artefact. Finally in study 4 in patients with suspected angina using CMR as an initial investigative strategy produced a significantly lower probability of unnecessary angiography compared to NICE guidance. There were similar rates of CAD detection were comparable suggesting no penalty for using functional imaging as a gatekeeper for angiography. Conclusion CMR has high diagnostic accuracy for the detection of coronary artery disease; with similar detection of ischaemic burden to established tests and can be used safely and effectively as a gate keeper to invasive coronary angiography.